gestational trophoblastic disease

Gestational Trophoblastic Disease

The uterus is affected by persistent trophoblast. The female reproductive system includes the uterus. It is a pear-shaped, hollow organ that is located between the bladder, rectum, and pelvis. During pregnancy, an unborn baby (or unborn baby) grows in the uterus, also known as the womb or unborn baby.

The uterus is divided into two: the cervix (the narrower, lower section) and the corpus (the broad, topmost section). (which is the wide, middle section). The dome-shaped fundus is the top section of the corpus. There are two layers of tissue in the uterine wall. The endometrium is the inner layer. The myometrium, which is the outer layer, is made up of muscle tissue. The following section provides illustrations of gynecologic anatomy.

Gestational Trophoblastic Disease

Persistent Trophoblastic Neoplasia

GTD refers to a rare group of tumors that can occur in pregnancy. They are found in the fetal choker, which is the outer portion of the sac that surrounds and protects the fetus during its growth. GTD can happen anytime throughout a pregnancy. GTD is treatable, especially if caught early.

This type of cancer occurs when normal placenta cells called trophoblast cells change to form a mass. GTD is generally benign. This means that it’s not cancerous. Some GTD tumors may be malignant. They can spread to other parts.

GTD is usually caused by problems in the combination of eggs and sperm. Trophoblast cells are normally found in the uterus and grow around fertilized eggs. They help to connect the egg to the uterine walls and form the placenta. The placenta, which is an organ that forms during pregnancy to supply nutrients to the fetus, is what you see. A healthy fetus is unlikely to develop if there are any problems with the tissues of your placenta. GTD can occur in rare cases. It is a form of cancer that develops from the normal placenta and may appear after normal pregnancy and birth.

Types of Gestational Trophoblastic Disease real image

Types of Gestational Trophoblastic Disease

GTD can be divided into two main groups. The first is molar pregnancy also known as hydatidiform mules. The second group is gestational trophoblastic neoneoplasia  (GTN). There are subtypes within each grouping, which are described below. Molar pregnancy (hydatidiform molles). About 80% of GTD is caused by molar pregnancies. Partial and complete molar pregnancies are the two types of molar pregnancies. Although they are benign and slow-growing, there is always the possibility that a mole could become cancerous. Complete molar pregnancies are more likely to develop cancer than partial ones.

A complete molecular pregnancy occurs when sperm fertilizes an unnatural egg without the mother’s DNA and nucleus. A healthy baby is extremely unlikely to ever be born. Instead of creating a fetus from the tissue, it forms a mass of cells that looks like grape-shaped cysts. A complete hydatidiform mole is yet another word for this.

The procreation of a normal egg with 2 different sperm starts a partial-molar pregnancy. This means that both the father and the mother possess two sets of DNA. Although the result may have some characteristics of a complete molar pregnancy, the baby is unlikely to develop. This mole is also acknowledged as a partial hydatidiform mole.

Mole that also is invasive real image


GTINs are often cancerous but can be linked to molar pregnancy. They get the chance to transmit to other parts of the body. The type and number of GTINs:

Mole that also is invasive.

This is an unique the kind molar pregnancy. An invasive mole, on the other hand, can be considered a GTN due to its ability to spread and grow. An invasive mole can grow into the muscle layer in the uterus. Only 15% of molar pregnancies are invasive and spread beyond the uterus.


A cancerous tumor that is formed from trophoblast cells. It can grow faster than other GTNs and can spread quickly. Choriocarcinoma could really spread to the uterine muscle and nearby capillaries, and also to distant organs such as the liver, kidneys, and brain. Choriocarcinoma makes up about 5% of all GTD. Most often, it is found in women who have experienced a molar birth. Choriocarcinoma is less common after an abortion, normal, or tubal birthWhen the baby is transplanted in the fallopian tube rather than on the uterus, this is meant to refer to as a fallopian tube pregnant women.

Placental site trophoblastic tumor (PSTT).

Placental site trophoblastic tumor (PSTT).

This rare type of GTN is also made from trophoblast cells. It begins where the placenta and also the uterus meet. Although it grows slowly, this type of tumor can spread to the uterine muscles, blood vessels, and lymph nodes nearby, as well as the pelvis and lungs. The signs and gestational trophoblastic disease symptoms of this type of tumor may not appear until after a normal gtd pregnancy or an abortion.

An epithelioid tumor (ETT).

This rare type of GTD is extremely rare. It can spread to the lungs if it does. It’s most common after a normal gtd pregnancy. Signs and symptoms can take time to manifest.

Differential Diagnosis of gestational trophoblastic disease (GTA)

  • Obstructive biliary behavior
  • Bladder cancer
  • Brain tumors
  • Cerebrovascular accidents
  • Hemorrhage cystitis: non-infectious
  • hCG secreting germ cell tumors
  • Nephrolithiasis
  • Ovarian choriocarcinoma
  • Pregnancy diagnosis
  • Quiescent GTN
  • Urothelial tumors in the renal pelvis or ureters

Leave a Comment